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Table 5 Randomized control trials of treatments for ARDS published after 1998

From: A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndrome

Author Derdak40 Eisner41 Gattinoni42 ARDS network43 Ely44 Lagneau45
Subjects All comers ARDS Pneumonia ARDS All comers ARDS All comers ARDS ARDS network (age <70) Pa02/FiO2 < 200
Intervention Ventilation-controlled or high frequency Tidal volume 12 ml/kg or 6 ml/kg Supine vs. prone Placebo vs. ketoconazole Tidal volume 12 ml/kg or 6 ml/kg Cisatracurium 0/4 twitches or 2/4 twitches
# of subjects 147 320 304 234 729 102
Mean age (yrs) 49 51 58 53 46 56
Severity of illness 22** 84*** 40* 81*** 73*** 41*
Pa02/FiO2 113 133 127 145   130
ICU days      19  
Days on ventilator 21     10  
In-hospital mortality     35%   45%
% with unassisted breathing at 1 mth   57%   59%   
10 day mortality    25%, 21%    
30 day mortality 52%, 37%     25%  
6 mth mortality 59%, 47% 36% 59%, 63%   30%  
Ventilator free days in first 28 days     10   
reintubation      7.5%