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Table 8 Feature description for our dataset

From: CNFE-SE: a novel approach combining complex network-based feature engineering and stacked ensemble to predict the success of intrauterine insemination and ranking the features

Variable

Variable levels

Variable type

Endoscopy-hysteroscopy

0, 1st Hysteroscopy, 1st Hysteroscopy | 2nd Hysteroscopy, 1st Hysteroscopy | 2nd Hysteroscopy | 3rd Hysteroscopy,, 3rd Hysteroscopy | 1st Hysteroscopy, 4th Hysteroscopy | 3rd Hysteroscopy | 1st Hysteroscopy | 2nd Hysteroscopy

Nominal

Endoscopy-laparoscopy

0, 1st laparoscopy, 1st laparoscopy | 2nd laparoscopy, 2nd laparoscopy

Nominal

Endocrine disorder-pituitary

0, acromegaly, Prolactinoma

Nominal

History-Habit

0, Alcohol, Alcohol | smoking, smoking

Nominal

Medical HX-neuro psychological

0, Anxiety, depression, depression | Epilepsy, Epilepsy, Psychotic disorder

Nominal

Medical HX-GI

0, Appendicitis, IBD, IBS, IBS | Peptic ulcer, Peptic ulcer

Nominal

Medical HX-immunologic disorder

0, Arthritic rheumatoid, lupus

Nominal

Medical HX-respiratory disease

0, Asthma, Bronchiectasis, bronchitis, bronchitis | Asthma

Nominal

Common surgery-orchiopexy

0, Bilat, Bilat | Left | Right, Left, Right, Right | Left

Nominal

Common surgery-varicocelectomy

0, Bilat, Left, Left | Bilat | Right, Left | Right, Right

Nominal

Common surgery-hernia

0, Bilat, Left, Left | Right, Left | Right | Bilat, Right

Nominal

Common surgery-hydrocele

0, Bilat, Left, Right

Nominal

History-nipple discharge

0, Bilateral, Bloody, Unilateral

Nominal

Current drug-antihyperprolactinemia

0, Bromocriptin, Bromocriptin | Dostinex, Dostinex

Nominal

Medical HX-infection disorder

0, Brucellosis, Hepatitis A, Hepatitis B, Hepatitis C, Herpes, TB

Nominal

Endocrine disorder-thyroid

0, cancer, Hyper, Hyper | Hypo, Hypo, Nodule

Nominal

Medical HX cardiovascular disorder

0, DVT, Heart failure, Hypertension, Hypertension | MVP, MVP

Nominal

Menstrual criteria-with drug

0, Estrogen, OCP, Progesterone, Progesterone | Estrogen, Progesterone | OCP

Nominal

History-pelvic infection HX

0, Frequent discharge, History Of PID

Nominal

Current drug-antidiabetic

0, Glucophage, Metformin, Metformin | Glucophage, Metformin | Paraovarian cyst, Paraovarian cyst

Nominal

LT G

0, II, II | III, II | Time of Injection, III, Time of Injection

Nominal

RT G__1

0, II, II | Time of Injection, Time of Injection

Nominal

LT G__1

0, III, Time of Injection

Nominal

Medical HX-blood disorder

0, Iron anemia, Major thalassemia, minor thalassemia

Nominal

Common surgery-orchiectomy

0, Left, Right

Nominal

Current drug-thyroid drugs

0, Levothyroxin, Levothyroxin | metimazole, metimazole, PTO

Nominal

Past-irreg

0, Oligomenorrhea, Poly menorrhea

Nominal

Medical HX-renal disease

0,Recurrent infection, Renal anomaly, Renal stone

Nominal

Diabetes-1st degree relative

0,Type I, Type I | Type II, Type II

Nominal

Endocrine disorder-D.M

0, type1, type2

Nominal

diagnosis-Uterine F

adenomyosis, Anomaly, Asherman, Myoma, Negative, Unexplained (thin endometrium)

Nominal

diagnosis-ovulatory F

Age factor, Diminished ovarian reserve, Endocrine problem, Hypothalamic hypogonadism, Negative, PCOS

Nominal

Therapeutic-agglutination

all, few, most, none, some

Nominal

Specimen characteristics-color

Amber-Yellow, gray | yellow, Grey, Light-Yellow, Milky, White, White–Grey

Nominal

Therapeutic-type of sampling

Coitus, Coitus | Masturbation, Masturbation, Retrograde ejaculation, Retrograde ejaculation | Coitus

Nominal

Therapeutic sperm preparation -technique

Discontinuous gradient, Pure sperm | Discontinuous gradient, Swim up, Swim up | Discontinuous gradient

Nominal

diagnosis-recurrent abortion

Endocrine, Male, Negative, Thrombotic, unexplained

Nominal

Tuboperitoneal type

Endometriosis, EP Hx, hydrosalipinx, Idiopathic, Negative, Post surgery

Nominal

diagnosis-unexplained

Endometriosis, Idiopathic, Negative

Nominal

diagnosis-other diagnosis

Genetic, Impotency, Incomplete data, Negative, other, poor obstetric outcome, sex selection, Vaginismus

Nominal

Menstrual criteria-amount

hypermenorrhea, Hypo menorrhea, Normal

Nominal

IUI clinic-IUI catheter

INDOVASIVE, Other, INDOVASIVE | Other, Catheter Impex, ORI

Nominal

Past-type

more than 8 levels

Nominal

Surgical HX-non gynecologic surgery

more than 8 levels

Nominal

DRUG HX-past drug

more than 8 levels

Nominal

Male medical information-exposures

more than 8 levels

Nominal

Male medical information-drug Hx esp

more than 8 levels

Nominal

Coded after processing-progression

more than 8 levels

Nominal

Coded before processing-progression

more than 8 levels

Nominal

Therapeutic-viscosity

Normal, Somewhat Thick, Thick, Thin, Very thick

Nominal

Specimen characteristics-viscosity

Normal, Somewhat Thick, Thick, Very Thick

Nominal

Family history endocrine disorder-thyroid

NO, YES

Binominal

Male medical information-scrotum

Ab, NL

Binominal

Specimen characteristics-collect type

C, M

Binominal

Therapeutic-place of sampling

In, Out

Binominal

Therapeutic-SPLIT Ejaculation

NO, YES

Binominal

Menstrual Criteria-Interval

Normal (22–35 days), Abnormal (< 21, > 36 days)

Binominal

Infertility type

primary, secondary

Binominal

Relationship-First cousin

0,1

Binary

Relationship-distant relationship

0,1

Binary

No relationship

0,1

Binary

Diagnosis-Male factor

0,1

Binary

Past-Reg (menstruation)

0,1

Binary

Current-Reg (menstruation)

0,1

Binary

Irreg-Oligomenorrhea

0,1

Binary

Irreg-Poly menorrhea

0,1

Binary

Cycle-Amenorrhea

0,1

Binary

Amenorrhea-Primary

0,1

Binary

Amenorrhea-Secondary

0,1

Binary

Menstrual Criteria-IMB

0,1

Binary

Coital HX-Lubricant

0,1

Binary

Coital HX-PCB

0,1

Binary

Coital HX-Vaginismus

0,1

Binary

Coital HX-Impotency

0,1

Binary

History-Cytotoxic Therapy

0,1

binary

Allergy-food

0,1

Binary

Allergy-seasonal

0,1

Binary

Allergy-Skin

0,1

Binary

Allergy-respiratory

0,1

Binary

Family history-infertility

0,1

Binary

Family history-recurrent abortion

0,1

Binary

Family history-POF

0,1

Binary

Family history-hearing disorder

0,1

Binary

Family history-TB

0,1

Binary

Family history-mental retardation

0,1

Binary

Cardio vascular-myocardial infarction

0,1

Binary

Cardio vascular-HTN

0,1

Binary

Respiratory disorder-Asthma

0,1

Binary

Thalassemia-minor

0,1

Binary

Type of cancer-breast cancer

0,1

Binary

Type of cancer-colon cancer

0,1

Binary

Type of cancer-leukemia

0,1

Binary

Type of cancer-uterus cancer

0,1

Binary

Type of cancer-lung cancer

0,1

Binary

Family history-epilepsy

0,1

Binary

Antihyperprolactinemia-Bromocriptin

0,1

Binary

Antihyperprolactinemia-Dostinex

0,1

Binary

Current drug-Anti Depression

0,1

Binary

Current drug-Anti hypertension

0,1

Binary

Current drug-Anticoagulant

0,1

Binary

Current drug-Folic acid

0,1

Binary

Current drug-Estrogen

0,1

Binary

Current drug-Progestron

0,1

Binary

Current drug-Ferrous sulphate

0,1

Binary

Current drug-Multi vitamin

0,1

Binary

Physical Exam-hirsutism

0,1

Binary

Type of pregnancy-Clinical pregnancy (class variable)

0,1

Binary

Minimal stimulation-Gonadotropin

0,1

Binary

Minimal stimulation-Letrosol

0,1

Binary

Minimal stimulation-Clomiphen

0,1

Binary

Type-Cetrorelix

0,1

Binary

HCG.IU_5000

0,1

Binary

HCG.IU_10000

0,1

Binary

HCG.IU_15000

0,1

Binary

Buserelin_0.5 cc

0,1

Binary

Ovitrelle_250 mgr

0,1

Binary

Ovitrelle_500 mgr

0,1

Binary

Type-Fostimon

0,1

Binary

Type-Gonal.F

0,1

Binary

Type-Menopour

0,1

Binary

Type-HMG

0,1

Binary

Type-Merional

0,1

Binary

Type-Bravelle

0,1

Binary

Before Stimulation-OCP

0,1

Binary

Before Stimulation-Estradiol

0,1

Binary

Cotreatment-Aspirin

0,1

Binary

Adjuvant therapy-Acid folic

0,1

Binary

Right-PCO

0,1

Binary

Right-Cyst

0,1

Binary

Left-PCO

0,1

Binary

Left-Cyst

0,1

Binary

Endometrial Texture-Three line

0,1

Binary

have you married before-yes

0,1

Binary

did you have any child-no

0,1

Binary

Common surgery-T.BX

0,1

Binary

Common surgery-Vasectomy

0,1

Binary

Uncommon surgery-Urethral stricture

0,1

Binary

Uncommon surgery-Brain surgey

0,1

Binary

Medical history-Mumps

0,1

Binary

Medical history-Hypertension

0,1

Binary

Medical history-Veneral Dz

0,1

Binary

Medical history-Allergy

0,1

Binary

Medical history-D.M

0,1

Binary

Medical history-M orchitis

0,1

Binary

Medical history-Test Pain

0,1

Binary

Medical history-TB

0,1

Binary

Medical history-Epididimorchitis

0,1

Binary

Medical history-UDT

0,1

Binary

Medical history-UTI

0,1

Binary

Cigarette-occasionally

0,1

Binary

Cigarette-quarter pack per day

0,1

Binary

Cigarette-half pack per day

0,1

Binary

Cigarette-one pack per day

0,1

Binary

Cigarette-two packs per day

0,1

Binary

Cigarette-three packs per day

0,1

Binary

Alcohol-occasionally

0,1

Binary

Alcohol-one per week

0,1

Binary

Opium-occasionally

0,1

Binary

Opium-one per day

0,1

Binary

Marital status of brothers-Married

0,1

Binary

Marital status of brothers-New couples

0,1

Binary

Family HX of infertility-Do your brothers have any children

0,1

Binary

Right testicle Size_less than 1

0,1

Binary

Right testicle Size_1-1.5

0,1

Binary

Right testicle Size_1.5–2

0,1

Binary

Right testicle Size_2-2.5

0,1

Binary

Right testicle Size_2.5–3

0,1

Binary

Right testicle Size_3-3.5

0,1

Binary

Right testicle Size_3.5–4

0,1

Binary

Right testicle Size_more than 4

0,1

Binary

Left testicle size_less than 1

0,1

Binary

Left testicle size_1-1.5

0,1

Binary

Left testicle size_1.5–2

0,1

Binary

Left testicle size_2-2.5

0,1

Binary

Left testicle size_2.5–3

0,1

Binary

Left testicle _3-3.5

0,1

Binary

Left testicle size_3.5–4

0,1

Binary

Left testicle size_more than 4

0,1

Binary

Vas-RT

0,1

Binary

Vas-LT

0,1

Binary

RT-NL

0,1

Binary

RT-Ab

0,1

Binary

LT-NL

0,1

Binary

RT-G

0,1

Binary

plan-med treatment

0,1

Binary

Vitamin-Vitamin C

0,1

Binary

Vitamin-Vitamin E

0,1

Binary

Plan-S.A

0,1

Binary

Plan-Imaging

0,1

Binary

Plan-H.A

0,1

Binary

Plan-CW

0,1

Binary

Plan-KARYO

0,1

Binary

Plan-AZF

0,1

Binary

Plan-TESE

0,1

Binary

Plan-Wives visit by Gyn required

0,1

Binary

Plan-Varicocelectomy

0,1

Binary

Plan-sperm Freezing

0,1

Binary

Plan-PC.U.A

0,1

Binary

Plan-genetic consult

0,1

Binary

Plan-endocrine consult

0,1

Binary

Plan-DFI

0,1

Binary

Plan-stop smoking, alcohol, opium

0,1

Binary

Plan-Occupation hygiene

0,1

Binary

Plan-Low weight

0,1

Binary

Plan-Others

0,1

Binary

Morphology-Amorph

0,1

Binary

Morphology-giant head

0,1

Binary

Morphology-pin head

0,1

Binary

Morphology-round head

0,1

Binary

Morphology-cytoplasmic droplet

0,1

Binary