Table 2 Top 10 OR results for 4-drug combination vs. 1-drug: with Bonferroni correction, a significant p is 3.75E-7
From: Mining and visualizing high-order directional drug interaction effects using the FAERS database
4-drug combination | 1-drug combination | OR | p-value |
|---|---|---|---|
Fentanyl, Gabapentin, Levofloxacin, Zoledronate | Fentanyl | 43.30 | 6.52E-181 |
Fentanyl, Levofloxacin, Omeprazole, Zoledronate | Fentanyl | 38.79 | 2.03E-168 |
Ciprofloxacin, Fentanyl, Levofloxacin, Zoledronate | Fentanyl | 36.70 | 1.15E-157 |
Acetaminophen, Doxorubicin, Omeprazole, Zoledronate | Doxorubicin | 35.40 | 4.44E-114 |
Capecitabine, Dexamethasone, Fentanyl, Zoledronate | Capecitabine | 34.36 | 9.61E-100 |
Alprazolam, Fentanyl, Levofloxacin, Zoledronate | Fentanyl | 34.33 | 1.19E-146 |
Acetaminophen, Doxorubicin, Levofloxacin, Zoledronate | Doxorubicin | 33.53 | 4.23E-113 |
Ciprofloxacin, Fentanyl, Levofloxacin, Oxycodone | Fentanyl | 33.40 | 2.10E-146 |
Fentanyl, Gabapentin, Metoclopramide, Zoledronate | Metoclopramide | 33.13 | 4.86E-117 |
Docetaxel, Oxycodone, Prochlorperazine, Zoledronate | Docetaxel | 32.97 | 1.57E-140 |