Table 3 Top 10 OR results for 4-drug combination vs. 2-drug: with Bonferroni correction, a significant p is 2.61E-7
From: Mining and visualizing high-order directional drug interaction effects using the FAERS database
4-drug combination | 2-drug combination | OR | p-value |
|---|---|---|---|
Gadobenate Dimeglumine, Gadodiamide, Gadoteridol, Prednisone | Gadobenate Dimeglumine, Prednisone | 270.16 | 8.81E-09 |
Pamidronate, Sulfamethoxazole, Trimethoprim, Zoledronate | Pamidronate, Sulfamethoxazole | 85.71 | 4.87E-23 |
Doxorubicin, Pamidronate, Vincristine, Zoledronate | Doxorubicin, Vincristine | 41.74 | 2.02E-129 |
Dexamethasone, Doxorubicin, Oxycodone, Vincristine | Doxorubicin, Vincristine | 36.77 | 2.59E-92 |
Dexamethasone, Doxorubicin, Pamidronate, Vincristine | Doxorubicin, Vincristine | 30.99 | 5.38E-108 |
Dexamethasone, Doxorubicin, Vincristine, Zoledronate | Doxorubicin, Vincristine | 30.52 | 6.37E-112 |
Acetaminophen, Diphenhydramine, Prochlorperazine, Zoledronate | Diphenhydramine, Prochlorperazine | 29.15 | 7.61E-62 |
Docetaxel, Oxycodone, Prochlorperazine, Zoledronate | Docetaxel, Prochlorperazine | 28.95 | 9.23E-79 |
Acetaminophen, Cyclophosphamide, Doxorubicin, Pamidronate | Cyclophosphamide, Doxorubicin | 27.76 | 1.79E-85 |
Docetaxel, Furosemide, Oxycodone, Zoledronate | Docetaxel, Furosemide | 27.32 | 5.22E-58 |