Development and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains

Table 1 Health-related quality of life (HRQoL) domains at baseline and follow-up of the entire study population in the non-imputed dataset (N = 1458)

	HRQoL at T0		HRQoL at T2		Dichotomized HRQoL groups			HRQoL changes from T0 to T2
	N	Mean (SD)	N	Mean (SD)	MID ^b	Cut-off ^c	Low HRQoL at T2 N (%) ^c	Consistently low HRQoL N (%) ^d	Deteriorating HRQoL N (%) ^d
Global quality of life ^a	1429	78.1 (17.2)	1170	78.3 (17.2)	10	68.1	341 (23.4%)	205 (60.1%)	129 (37.8%)
Cognitive Functioning ^a	1426	85.5 (19.4)	1167	86.6 (18.7)	7	78.5	229 (15.7%)	159 (69.4%)	66 (28.8%)
Emotional Functioning ^a	1421	87.3 (18.5)	1164	88.2 (17.1)	12	75.3	270 (18.5%)	169 (62.6%)	93 (34.4%)
Physical Functioning ^a	1431	81.7 (19.4)	1168	81.7 (19.1)	10	71.7	278 (19.1%)	197 (70.9%)	78 (28.1%)
Role Functioning ^a	1423	81.9 (25.8)	1168	82.9 (25.1)	14	67.9	371 (25.4%)	238 (64.2%)	128 (34.5%)
Social Functioning ^a	1419	88.2 (20.0)	1165	89.1 (20.1)	11	77.2	233 (16.0%)	133 (57.1%)	95 (40.8%)
Fatigue ^a	1421	20.2 (22.2)	1157	20.5 (22.3)	10	30.2	349 (23.9%)	220 (63.0%)	118 (33.8%)

Footnotes:
^aHigher scores on global QoL and functioning domains represent better HRQoL, whereas higher scores on fatigue represent worse fatigue complaints. All domains scores can range from 0 to 100 points
^bMinimal important deterioration (MID) in EORTC QLQ-C30 domains published by Cocks et al. for each subscale [18]
^cPersons were classified as having ‘low HRQoL’ when their T2 score differed by ≥1 MID from the T0 group mean (below mean for global quality of life and functioning domains; above mean for fatigue)
^dPersons had consistently low HRQoL when both their T0 and T2 scores were ≥ 1 MID above/below the T0 group mean. Persons had deteriorating HRQoL when they decreased from normal/high HRQoL at T0 to a T2 score ≥ 1 MID below/above the T0 group mean (below mean for global quality of life and functioning domains; above mean for fatigue). The number of subjects with consistently low and deteriorating HRQoL do not add up to the total number in the low HRQoL group due to missings at T0

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