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Table 3 Indicator, algorithm, and data source for the included studies

From: Artificial intelligence performance in detecting lymphoma from medical imaging: a systematic review and meta-analysis

First author and year

Indicator definition

Algorithm

Data source

Method for predictor

Exclusion of poor quality imaging

Heatmap provided

Algorithm architecture

Transfer learning applied

Source of data

Number of images for training/internal/external

Data range

Open access data

Zhou Z, 2021

PET/CT images

N/A

N/A

DLCNN

Yes

Retrospective, data from 33 centers.

110/110/32

2007/05–2018/10

No

McAvoy M, 2021

MRI

Yes

N/A

CNN, EfficientNet

Yes

Retrospective, data from the Partners Healthcare Research Patient Data Registry (RPDR) web-based query tool.

1245/202/NR

2015–2018

No

Li D, 2020

Histopathology images

N/A

N/A

GOTDP-MP-CNNs

Yes

Retrospective, data from 3 hospitals.

80%/10%/NR

NR

Yes

Miyoshi H, 2020

WSI

N/A

N/A

DCNN

No

Retrospective, data from Kurume University.

388/NR/NR

2010–2017

NR

Park JE, 2020

Ultrasound

N/A

N/A

CART

No

Retrospective, data from a single center in US.

170/NR/72

2012–2018

NR

Mohlman JS, 2020

Histologic images

Yes

N/A

Deep dense CNN

Yes

Retrospective, data from hematopathology archives at author’s institutions.

8796/NR/NR

2010–2020

NR

Achi HE, 2019

WSI

N/A

N/A

DLCNN

No

Retrospective, data from Virtual Pathology at the University of Leeds and Virtual Slide Box from University of Iowa.

1856/464/NR

NR

NR

Im H, 2018

Holograms

N/A

N/A

CNN

No

Prospective.

3447/1723/NR

NR

Yes

Guan Q, 2019

Cytological images

No

No

DCNN, Inception-v3

Yes

Retrospective, data from a single center.

156/26/NR

2016.11–2017.11

NR

Guo R, 2021

PET/CT images

No

No

ResNet-18

No

Retrospective and prospective, data from Shanghai Ruijin Hospital.

64/20/NR

2011/06–2020/10

Yes

Xia W, 2021

MRI

N/A

N/A

IF-CNN

Yes

Retrospective, data from a single center.

80%/20%/NR

2011–2019

NR

Zhang Y, 2021

MRI

Yes

No

3D U-Net/Resnet18

No

Retrospective, data from two centers in China.

65/27/NR

2005.1–2019.12

Yes

Syrykh C, 2020

WSI

N/A

N/A

Stochastic BNN

No

Retrospective, data from the lymphopath database in Toulouse University Cancer Institute and Dijon University Hospital, France.

50%/25%/25%

NR

No

Wang H, 2020

PET/CT images

No

No

LASSO

No

Retrospective.

82/28/NR

2011/01–2017/01

NR

Zhang J, 2020

Histopathology images

No

N/A

VGG-16, VGG-19, ResNet-50, DenseNet-121

Yes

Retrospective, data from a reference dataset provided by Janowczyk et al.

269/30/NR

NR

NR

Wang Q, 2017

Microscopic blood images

No

No

ANN

No

Retrospective, data from the Department of Hematology, Ruijin Hospital, Shanghai, China.

27/NR/NR

NR

NR

Schouten JPE, 2021

Cytological images

No

No

CNN

No

Retrospective, data from the Department of Information Technology at the University of Milan.

200/25/25

NR

NR

Nakagawa M, 2018

MRI

N/A

N/A

Machine learning classifiers

No

Retrospective.

63/7/NR

2008.01–2013.12

NR

Shafique S, 2018

Microscopic blood images

No

No

DCNN

Yes

Retrospective, data from ALL-Image DataBase (IDB).

60%/40%/NR

NR

Yes

Kong Z, 2019

PET/CT images

N/A

Yes

Decision tree classifier

No

Retrospective, data from Peking Union Medical College Hospital.

80%/20%/NR

2010/01–2018/10

NR

Weisman AJ, 2020

PET/CT images

No

No

CNN

No

Retrospective, data from one of two separate prospective multicenter imaging trials.

65%/15%/20%

2005–2011

NR

Kim Y, 2018

mpMRI

Yes

No

Logistic regression-based classifier, random forest

No

Retrospective, data from two independent cohorts: the discovery cohort from Samsung Medical Center in Seoul, South Korea; and the validation cohort from Asan Medical Center in Seoul, South Korea.

36/36/28

2013/01–2016/02

NR

Styczeń M, 2012

Specimens

No

No

Neural network

No

Retrospective, data from the Department of Pathology.

NR/NR/NR

2005–2009

NR

Guo J, 2018

MRI

Yes

No

LASSO

No

Retrospective, data from a single center.

47/37/NR

2010/03–2016/07

NR

Azamossadat H, 2023

Microscopic blood images

No

No

CNN

Yes

Restrospective, data from several Tehran hospitals

85/5/10

NR

NR

Chava P, 2023

Biopsy slides

No

No

MIL

No

Restrospective, data from the Tel Aviv Sourasky Medical Center

55/NR/25

2017/01–2022/01

NR

Jermphiphut J, 2023

MRI

No

No

CNN

No

Restrospective, data from a historical cohort study

709/177/NR

2010/01–2021/12

NR

Hikaru A, 2023

PET/CT images

No

Yes

CNN

No

Restrospective, data from Nthe Tokyo Medical and Dental University, Tokyo, Japan, and Shinjuku Tsurukame Clinic, Tokyo, Japan.

62/NR/NR

2005/08–06/2020

NR

Manjit K, 2023

Peripheral blood smear images

No

No

DSCNet

No

Restrospective, data from Acute Lymphoblastic Leukemia Image Dataset

20,000/NR/NR

2021

Yes

Noriaki H, 2023

WSI

No

No

ResNet50

No

Restrospective, data from Kurume University and Nagoya University Hospital

249/NR/208

2018

NR

  1. NR not reported, MRI magnetic resonance imaging, mpMRI multi-parametric MRI, WSI whole slide image, CNN convolutional neural network, DCNN deep convolutional neural network, IF-CNN image-level fusion based multi-parametric CNN, CART classification and regression tree, DLCNN deep learning convolutional neural network, ResNet residual network, BNN bayesian neural network, LASSO least absolute shrinkage and selection operator, ANN artificial neural network, DSCNet deep skip connections-based dense network, MIL multiple instance learning algorithms