Table 2 Summaries of differential predictors and biomarkers used in the model for the development and validation datasets. (SD) [percentage of missing values]
Development Dataset | Validation Dataset | |||
|---|---|---|---|---|
Drug Taken | DPP4-inhibitor | SGLT2-inhibitor | DPP4-inhibitor | SGLT2-inhibitor |
(n = 9,974) | (n = 6,152) | (n = 6,650) | (n = 4,101) | |
Age (years) | 63.9 (10.8) | 59.9 (9.1) | 65.0 (10.7) | 60.2 (9.3) |
Number of Past Drugs | ||||
2 | 3,884 | 1,167 | 2,556 | 731 |
3 | 3,653 | 1,693 | 2,457 | 1,115 |
4 | 972 | 1,569 | 683 | 1,045 |
5+ | 186 | 945 | 117 | 672 |
Number of Current Drugs | ||||
0 | 523 | 149 | 309 | 93 |
1 | 5,078 | 2,191 | 3,424 | 1,418 |
2 | 3,000 | 2,449 | 1,993 | 1,643 |
3+ | 94 | 585 | 87 | 409 |
HbA1c (mmol/mol) | 72.9 (13.5) | 76.6 (14.2) | 72.6 (13.2) | 77.1 (14.1) |
eGFR (mL/min/1.3m2) | 83.1 (17.4) [0.2%] | 88.8 (14.7) [0.3%] | 84.9 (17.2) [0.2%] | 88.6 (14.8) [0.4%] |
ALT (IU/L) (logged) | 3.3 (0.5) [10.0%] | 3.4 (0.5) [10.4%] | 3.3 (0.5) [10.1%] | 3.4 (0.5) [10.8%] |
BMI (kg/m2) | 32.3 (6.4) [3.2%] | 34.4 (6.5) [2.4%] | 32.3 (6.4) [2.9%] | 34.4 (6.6) [2.5%] |
Outcome HbA1c (mmol/mol) | 65.1 (16.0) | 64.9 (14.2) | 65.0 (16.2) | 65.1 (14.6) |
HbA1c_Month: Month of outcome HbA1c | 9.2 (3.5) | 9.0 (3.5) | 9.2 (3.4) | 9.0 (3.4) |